Table_1_Circulating miRNA profiles and the risk of hemorrhagic transformation after thrombolytic treatment of acute ischemic stroke: a pilot study.xlsx

BackgroundHemorrhagic transformation (HT) in acute ischemic stroke is likely to occur in patients treated with intravenous thrombolysis (IVT) and may lead to neurological deterioration and symptomatic intracranial hemorrhage (sICH). Despite the complex inclusion and exclusion criteria for IVT and some useful tools to stratify HT risk, sICH still occurs in approximately 6% of patients because some of the risk factors for this complication remain unknown.ObjectiveThis study aimed to explore whether there are any differences in circulating microRNA (miRNA) profiles between patients who develop HT after thrombolysis and those who do not.MethodsUsing qPCR, we quantified the expression of 84 miRNAs in plasma samples collected prior to thrombolytic treatment from 10 individuals who eventually developed HT and 10 patients who did not. For miRNAs that were downregulated (fold change (FC) 1.5) with p

背景：急性缺血性卒中患者在接受静脉溶栓治疗（IVT）后，可能出现背景性出血性转化（HT），这可能导致神经功能恶化及症状性颅内出血（sICH）。尽管静脉溶栓的纳入和排除标准复杂，且存在一些有助于分层HT风险的工具，但约6%的患者仍会发生sICH，这是因为某些并发症的风险因素尚不明确。研究目的：本研究旨在探究在接受溶栓治疗后发生HT的患者与未发生HT的患者之间，是否存在循环微小RNA（miRNA）谱的差异。研究方法：利用定量PCR技术，我们对10名最终发生HT及10名未发生HT的患者在接受溶栓治疗前的血浆样本中84种miRNA的表达进行了量化分析。对于下调的miRNA（倍数变化（FC）1.5）进行p值检验，...