Background: Complex biological networks control fundamental processes such as reproduction. The relationship of network structure to biological function was investigated in a global gene interaction n
Shown are the number of genes and concordant edges for each BC3NET network component. The p-values were adjusted using a Bonferroni procedure. We annotated these network components by using the most e
We constructed a combinatorial CRISPR guide library to target ~200,000 pairwise combinations of 461 genes associated with DNA Repair. Overall design: eHAP-iCas9 cells harboring this library were grown