A Quinine-Squaramide Catalyzed Enantioselective Aza-Friedel–Crafts Reaction of Cyclic Trifluoromethyl Ketimines with Naphthols and Electron-Rich Phenols
收藏Figshare2016-02-12 更新2026-04-29 收录
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https://figshare.com/articles/dataset/A_Quinine_Squaramide_Catalyzed_Enantioselective_Aza_Friedel_Crafts_Reaction_of_Cyclic_Trifluoromethyl_Ketimines_with_Naphthols_and_Electron_Rich_Phenols/2106862
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资源简介：
A highly enantioselective aza-Friedel–Crafts (aza-F-C) reaction of cyclic trifluoromethyl ketimines and naphthols/phenols was developed with fluorenyl-substituted quinine-squaramide as the catalyst. This protocol enables direct access to biologically important chiral trifluoromethyl dihydroquinazolinones with up to 99% yields and up to 99% ee’s.
创建时间：
2016-02-12
