Supporting data for "Transcriptomic and Functional Analysis of Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Tetralogy of Fallot Patient with and without DiGeorge Syndrome"

Whole genome sequencing was performed on the human induced pluripotent stem cells (hiPSC) derived from tetralogy of Fallot (TOF) patients with or without DiGeorge Syndrome. Single cell RNA sequencing were then subsequently performed on the cardiac progenitors and the cardiomyocytes (CM) derived from patient-specific hiPSC. The electrophysiological profile of patient-specific-hiPSC-CM was assessed with the construction of cardiac anisotropic sheet (CAS).

对来自法洛四联症（TOF）患者，包括或不含迪乔治综合征的患者所衍生的人诱导多能干细胞（hiPSC）进行了全基因组测序。随后，对源自特定患者hiPSC的心脏祖细胞和心肌细胞（CM）进行了单细胞RNA测序。通过构建心脏各向异性板（CAS），对特定患者hiPSC-CM的电生理特征进行了评估。