Spreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Binding of Polycomb repressive complex 2 (PRC2) and chromatin composition of the inactive X (Xi) before, during and after X chromosome inactivation reveal that spreading is driven by a combination of Xi-specific strong and moderate Ezh2 sites. Sequence context of these sites shows a moderate enrichment of SINEs and simple repeats. The general pattern of Ezh2 and H3K27me3 distribution over the chromosome reflect a graded concentration originating from strong Ezh2 sites, around which moderate sites are clustered, suggesting a hierarchy of Ezh2 sites govern spreading.
提供机构：
Howard Hughes Medical Inst, Mass General Hospital, Harvard Medical School
创建时间：
2022-02-20
