Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06454589).
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Crystal structure of MST3 with a pyrrolopyrimidine inhibitor (PF-06454589). Descriptor: 5-(1-methyl-1H-pyrazol-4-yl)-4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine, Serine/threonine-protein kinase 24 36 kDa subunit Authors: Jasti, J, Song, X, Griffor, M, Kurumbail, R.G. Deposit date: 2014-08-24 Release date: 2015-03-18 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J.Med.Chem., 58, 2015
创建时间：
2014-08-24
