Transcriptome analysis of kidneys of acute-chronic (AC), unilateral ureteral obstruction (UUO) mice and their respective controls

Significant renal fibrosis and a significant increase in serum creatinine were observed in AC model mice and UUO model mice, and the same pattern of fibrosis was observed in the cortex and medulla. Compared with sham operation, RNA-Seq detected circRNAs that were differentially expressed in the two models. Overall design: Examination of three different groups: euthanized mice and harvested kidneys 5 days after I/R, UUO and Sham-operated mice served as controls