Smooth muscle cell reprogramming in aortic aneurysms [scRNA-Seq]

Smooth muscle cell TGFβ signaling is one of the primary drivers of smooth muscle cell maturation. Inhibition of smooth muscle cell TGFβ signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed scRNAseq method to examine smooth muscle cell gene expression profile using Apoe and SMC specific TGFbR2 KO in Apoe background mice. Using scRNAseq to compare the gene expression profiles of smooth muscle cells beteewn ApoE mice and SMC specific TGFbR2 KO Apoe mice fed with high fat diet