Suppression of Ribosome Biogenesis Underlies Aging-Like Symptoms Following COVID-19: Multi-Omics Investigations with Aging Clock (RiboAge)

Matrix for clinical data. Clinical data matrix containing demographic characteristics, laboratory measurements, and clinical parameters of all study participants. Matrix for metabolites. Raw intensity matrix of plasma metabolomics data acquired by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Matrix for mRNA_count. Raw read count matrix generated from PBMC RNA‑sequencing transcriptomic data. Matrix for mRNA_tpm. TPM (transcripts per million) normalized expression matrix derived from the PBMC RNA‑seq dataset. Matrix for protein. Raw abundance matrix of plasma proteomics data obtained via mass spectrometry. zhushi_gene. Gene annotation table for the transcriptomic data, including gene symbols, Ensembl IDs, and genomic coordinates. zhushi_protein. Protein annotation table for the proteomic data, providing protein names, UniProt accession numbers, and corresponding gene symbols. zhushi_metabolitics. Metabolite annotation table for the metabolomic data, containing metabolite names, HMDB IDs, and associated KEGG pathway information.