Analysis of altered miRNA expression profiles in the streptozotocin-induced diabetic rats compared to normal SD rats

Diabetes mellitus (DM) is one of the most common chronic diseases around the world, and diabetic peripheral neuropathy (DPN) is one of the most common complications of DM. We used microarrays to identify the differentially expressed miRNAs in dorsal root ganglia (DRG) tissues from streptozotocin (STZ)-induced diabetic rats, taking normal SD rats as controls, and tried to find out the related genes which may be involved in the development of DPN.糖尿病（Diabetes mellitus, DM）是全球范围内最常见的慢性疾病之一，而糖尿病周围神经病变（Diabetic Peripheral Neuropathy, DPN）是DM最常见的并发症之一。本研究通过基因芯片技术，以正常SD大鼠为对照，对链脲佐菌素（Streptozotocin, STZ）诱导的糖尿病大鼠背根神经节（Dorsal Root Ganglia, DRG）组织中的差异表达微小RNA（miRNAs）进行鉴定筛选，旨在挖掘可能参与DPN发生发展的相关基因。