IPD-KIR - Killer-cell Immunoglobulin-like Receptors

The database provides a centralised repository for human KIR sequences. Killer-cell Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at the allelic and haplotypic level. KIRs are members of the immunoglobulin superfamily (IgSF) formerly called Killer-cell Inhibitory Receptors. They are composed of two or three Ig-domains, a transmembrane region and cytoplasmic tail which can in turn be short (activatory) or long (inhibitory). The Leukocyte Receptor Complex (LRC) which encodes KIR genes has been shown to be polymorphic, polygenic and complex like the MHC.本数据库为人类杀伤细胞免疫球蛋白样受体（Killer-cell Immunoglobulin-like Receptors，KIR）序列提供了集中式存储库。现已证实，KIR在等位基因与单倍型层面呈现高度多态性。KIR属于免疫球蛋白超家族（immunoglobulin superfamily，IgSF）的成员，曾被称为杀伤细胞抑制性受体。该受体由2至3个免疫球蛋白结构域、一段跨膜区域以及胞质尾构成，胞质尾可分为短尾（激活型）与长尾（抑制型）两类。编码KIR基因的白细胞受体复合物（Leukocyte Receptor Complex，LRC）现已被证实具有多态性、多基因性且结构复杂，与主要组织相容性复合体（Major Histocompatibility Complex，MHC）类似。

搜集汇总

背景与挑战

背景概述

IPD-KIR数据库是一个集中存储人类杀伤细胞免疫球蛋白样受体（KIR）序列的仓库。KIR具有高度多态性，属于免疫球蛋白超家族，由多个结构域组成，其编码基因位于多态性且复杂的白细胞受体复合体中。