Alterations of gut microbiota in a mouse model with partial small intestinal obstruction. feces metagenome

In this study, we aimed to explore the alterations of microbiota in an animal model of PSIO, to gain insight into the mechanism of PSIO-induced pathophysiological changes. Our study reveals prominent alterations in gut microbial diversity within PSIO mice, characterized by a reduction in beneficial bacterial populations and a concurrent rise in opportunistic pathogens. Furthermore, we observed a diminished metabolic capacity of the fecal microbiota attributed to the presence of PSIO. Additionally, we noted an enrichment of pathways related to intestinal fibrosis within the intestinal epithelium of PSIO mice. Our findings suggest that clarifying the composition and function of the gut microbiota in PSIO may help to better understand the mechanism of PSIO-associated complications, which might be a potential therapeutic strategy to maintain intestinal and systemic homeostasis in such patients.