Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, but Ang(1-7) is Not the Ligand

Sugen-hypoxic Mice treated with ACE2, a MAS agonist AR234960, or a peptidase inhibitor Alt00 Overall design: Mice are put in 10% O2 for three weeks, and receive injections of the vegf inhibitor Sugen weekly, to induce pulmonary hypertension. They are simultaneously treated with either vehicle, ACE2, AR234960, or Alt00+Lisinopril