Rabson Mendenhall syndrome meta-analysis dataset

PubMed, Embase, the China National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched from their inception until August 7, 2023, without any language limitations. The search strategies employed the following terms: 'Rabson-Mendenhall syndrome' or 'Black acanthosis hirsutism insulin resistance syndrome'. All included studies fulfilled the following eligibility criteria: (1) patients were definitively diagnosed with Rabson-Mendenhall syndrome through DNA testing and clinical assessment; (2) the references provided either comprehensive clinical data of the probands or documented mutations in the INSR gene. The flow chart showed identification articles included and the reasons for their exclusions. The present study examined various clinical and laboratory variables, including: (1) country and area of origin; (2) age at the time of diagnosis; (3) gender; (4) body mass index (BMI); (5) familial history; (6) clinical characteristics; (7) diabetes therapy, encompassing oral hypoglycemic agents (OHA), insulin, and dietary interventions; (8) laboratory test results at the time of diagnosis, encompassing fasting plasma glucose (FPG), fasting insulin (Fins), 2-hour postprandial plasma glucose (2-h PG), 2-hour postprandial insulin (2-h Ins), Glycosylated Hemoglobin (HbA1c); and (9) identification of amino acid substitutions and mutations, along with their respective types and locations within each gene.