Foxp3+CD8+ regulatory T cells (CD8 Tregs) help to establish immune tolerance in models of chronic inflammation and antigen stimulation, such as graft versus host disease and chronic infections. Howeve
Processed experimental data, model initial conditions, and simulation outputs supporting the manuscript: “Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responses.” This
Histone deacetylases (HDACs), as important enzymes regulating acetylation, participate in a series of cell physiological process. Here we reported that HDAC3-deficient macrophages had elevated express
Interleukin-7 (IL-7) was discovered in the year 1988 as a factor that enhanced the growth of murine B-cell precursors in bone marrow culture system. It was also known as lymphopoietin 1and pre-B cell
Aplastic anemia (AA) is a life-threatening disease primarily caused by a metabolic disorder and an altered immune response in the bone marrow (BM) microenvironment, where cytotoxic immune cells attack
