Estimates of the plateau enrichment of monocytes in humans.

The maximum level of label that monocytes can attain (expressed as a percentage) was estimated for a one-day D2-glucose labeling study (subjects C02-C10) and a seven-day D2-glucose labeling study (subjects C2–C4). Two different models were considered: the “BM”(bone marrow) model and the “delayed obs.” (delayed observation) model (Methods). We also calculated the average estimate of the plateau by weighing each fit with the corresponding Akaike weight [24]; these estimates are given in the column “weighted”. Estimates are shown ± standard deviation (sd). The sd in the “weighted” column reflects model uncertainty (whereas sd for the specified models assumes the model is correct). For every model the plateau enrichment was significantly higher in the one-day labeling study than in the seven-day labeling study (P = 0.048, P = 0.012, P = 0.012 for the BM, delayed obs. and weighted model respectively, two-tailed Mann-Whitney). In the one-day labeling study virtually all the plateau estimates were higher than 100% (23/24 ≥ 100%, 1/24 <100%); for the seven-day labeling study estimates were evenly distributed either side of 100% (4/9 ≥ 100%, 5/9 < 100%).
Estimates of the plateau enrichment of monocytes in humans.