Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus
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下载链接：
https://figshare.com/articles/dataset/Discovery_of_4_5_6_7-Tetrahydropyrazolo_1_5-a_pyrizine_Derivatives_as_Core_Protein_Allosteric_Modulators_CpAMs_for_the_Inhibition_of_Hepatitis_B_Virus/24261242
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资源简介：
Hepatitis B Virus (HBV) core protein allosteric modulators
(CpAMs)
are an attractive class of potential anti-HBV therapeutic agents.
Here we describe the efforts toward the discovery of a series of 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine (THPP) compounds as HBV CpAMs that effectively
inhibit a broad range of nucleos(t)ide-resistant HBV variants. The
lead compound 45 demonstrated inhibition of HBV DNA viral
load in a HBV AAV mouse model by oral administration.
创建时间：
2023-10-06
