The genomic landscape of relapsed infant and childhood KMT2A-rearranged acuteleukemia

This dataset includes whole genome and whole exome sequencing of diagnostic, germline, and relapse samples of 21 infants and 12 children with relapsed ALL (n=21) or AML (n=12), and targeted deep sequencing of 258 samples taken during treatment for 30 infants or children with ALL or AML. All patients had an underlying rearrangement of the KMT2A geneWhole genome and exome sequencing was performed using Illumina TruSeq Nano protocol. Targeted sequencing libraries was prepared using Nextera XT DNA Sample Preparation Kit (Illumina) and sequenced on the Illumina MiSeq.

本数据集涵盖了21名诊断性、原发性和复发ALL（n=21）或AML（n=12）儿童的全基因组及全外显子测序数据，以及30名ALL或AML婴儿或儿童在治疗期间采集的258个样本的靶向深度测序数据。所有患者均存在KMT2A基因的内在重排。全基因组及全外显子测序采用Illumina TruSeq Nano协议进行。靶向测序文库的制备采用Illumina Nextera XT DNA样本制备试剂盒，并在Illumina MiSeq平台上进行测序。