Hippocampal expression data from WT, KO, R270X, and G273X mice at 4 and 9 weeks

Mecp2 loss-of-function has been associated with altered gene expression in many tissues. We characterized gene expression changes within the hippocampi of 3 different Mecp2 loss-of-function mouse models. These studies were used to identify transcriptional differences between these mutants when the mice are largely asymptomatic (4 weeks of age) or have developed overt phenotypes (9 weeks). Hippocampal expression data from WT (Mecp2+/y), KO (Mecp2-/y), R270X (Mecp2-/y,R270XTg), and G273X (Mecp2-/y,G273XTg) mice at 4 and 9 weeks At total of 32 microarrays were performed: 4 animals of each genotype at both 4 weeks and 9 weeks of age.Mecp2功能丧失已被证实与多种组织的基因表达异常相关。本研究对3种不同的Mecp2功能丧失小鼠模型的海马体基因表达变化进行了系统表征。本研究旨在鉴定这些突变模型在小鼠基本无症状（4周龄）或已出现显性表型（9周龄）时的转录组差异。实验采集了野生型（WT，Mecp2+/y）、敲除型（KO，Mecp2-/y）、R270X（Mecp2-/y,R270XTg）以及G273X（Mecp2-/y,G273XTg）小鼠在4周龄和9周龄时的海马体基因表达数据。本研究共计完成32组微阵列实验：每种基因型在4周龄和9周龄时各纳入4只实验动物。