Target sequence recognition by the calmodulin superfamily: implications from light chain binding to the regulatory domain of scallop myosin.
收藏PubMed Central1995-11-07 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC40668/
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资源简介：
Some of the rules for how members of the calmodulin (CaM) superfamily bind to target peptides are revealed by the crystal structure of the regulatory domain of scallop myosin. The structure shows that the IQ motif of the heavy chain in this invertebrate myosin imposes constraints on both the positioning and conformation of the individual lobes of the light chains. In contrast, analysis of the contact residues in the targets bound by Ca(2+)-CaM reveals how the structure of CaM accommodates a broader range of sequences consonant with this protein's functional diversity. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-11-07
