CIDR: Collaborative Study on the Genetics of Alcoholism (COGA)

This is a case-control study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the

Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US.

COGA has gathered detailed, standardized data on study participants, including diagnostic and neurophysiological assessments.

This sample has already proved successful in identifying several genes that influence the risk for alcoholism and

neurophysiological endophenotypes, which have been independently replicated. COGA data were included as part of two Genetic

Analysis Workshops, and the phenotypes are familiar to the genetics community.

Alcoholic probands were recruited from treatment facilities, assessed by personal interview, and after securing permission,

other family members were also assessed. A set of comparison families was drawn from the same communities as the families

recruited through an alcoholic proband. Assessment involved a detailed personal interview developed for this project, the

Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), which gathers detailed information on alcoholism related

symptoms along with other drugs and psychiatric symptoms. Many participants also came to the laboratories for

electroencephalographic studies. Neurophysiological features that have been shown to be useful endophenotypes for which

we have linkage and in some cases association results are included on a subset of the case-control sample: the beta power of

the resting electroencephalogram (EEG), the P3(00) amplitude of the visual event-related potential (ERP), and the theta and

delta event-related oscillations (EROs) underlying the P3 (See Porjesz et al., 2005; Porjesz and Rangaswamy, 2007 for reviews).

A brief description of COGA is in Edenberg, H. J. (2002) The Collaborative Study on the Genetics of Alcoholism: an update.

Alcohol Res Health 26, 214-218., Bierut, LJ, NL Saccone, JP Rice, A Goate, T Foroud, HJ Edenberg, L Almasy, PM Conneally, R Crowe,

V Hesselbrock, T-K Li, JI Nurnberger, Jr, B Porjesz, MA Schuckit, J Tischfield, H Begleiter, and T Reich (2002) Defining

alcohol-related phenotypes in humans: The Collaborative Study on the Genetics of Alcoholism. Alcohol Res Health 26, 208-213.

Edenberg HJ and Foroud T (2006) The genetics of alcoholism: identifying specific genes through family studies. Addiction

Biology 11, 386-396.

This case-control sample of biologically unrelated individuals was drawn from COGA subjects. All cases meet DSM-IV criteria

for alcohol dependence. Controls are individuals who have consumed alcohol, but did not meet any definition of alcohol

dependence or alcohol abuse, nor did they meet any DSM-IIIR or DSM-IV definition of abuse or dependence for other drugs

(except nicotine). All cases and controls have undergone identical clinical assessments. Many individuals in this case-control

sample have not previously been genotyped.

The Collaborative Study on the Genetics of Alcoholism (COGA) has four Co-Principal Investigators: B. Porjesz,

V. Hesselbrock, H. Edenberg, L. Bierut. COGA includes nine different centers where data collection, analysis, and

storage take place. The nine sites and Principal Investigators and Co-Investigators are: University of Connecticut

(V. Hesselbrock); Indiana University (H.J. Edenberg, J. Nurnberger Jr., T. Foroud); University of Iowa (S. Kuperman); SUNY

Downstate (B. Porjesz); Washington University in St. Louis (L. Bierut, A. Goate, J. Rice); University of California at San Diego

(M. Schuckit); Howard University (R. Taylor); Rutgers University (J. Tischfield); Southwest Foundation (L. Almasy). Q. Max Guo

serves as the NIAAA Staff Collaborator. This national collaborative study is supported by the NIH Grant U10AA008401 from the

National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA). Funding support for

genotyping, which was performed at the Johns Hopkins University Center for Inherited Disease Research, was provided by the National

Institute on Alcohol Abuse and Alcoholism, the NIH GEI (U01HG004438),and the NIH contract "High throughput genotyping for studying

the genetic contributions to human disease" (HHSN268200782096C).

COGA has over 250 publications listed at www.niaaagenetics.org]]>
Description of the Visual Oddball Experiment (vp3) and Data ExtractionSSAGA I: Table of ContentsSSAGA I: A. DEMOGRAPHICSSSAGA I: B. MEDICAL HISTORYSSAGA I: C. SOMATIZATIONSSAGA I: D. TOBACCOSSAGA I: E. ALCOHOLSSAGA I: F. MARIJUANASSAGA I: G. DRUGSSSAGA I: H. EATING DISORDERSSSAGA I: I. DEPRESSIONSSAGA I: J. DYSTHYMIASSAGA I: K. MANIASSAGA I: L. PSYCHOSISSSAGA I: M. ANTISOCIAL PERSONALITYSSAGA I: N. SUICIDAL BEHAVIORSSAGA I: O. PANICSSAGA I: P. AGORAPHOBIA/SOCIAL PHOBIASSAGA I: Q. OBSESSIVE/COMPULSIVESSAGA I: R. SUBJECT COMMENTSSSAGA I: S. COMORBIDITYSSAGA I: T. INTERVIEWER'S OBSERVATIONSSSAGA II: A. DEMOGRAPHICSSSAGA II: B. MEDICAL HISTORYSSAGA II: C. SOMATIZATIONSSAGA II: D. TOBACCOSSAGA II: E. ALCOHOLSSAGA II: F. MARIJUANASSAGA II: G. DRUGSSSAGA II: H. EATING DISORDERSSSAGA II: I. DEPRESSIONSSAGA II: J. DYSTHYMIASSAGA II: K. MANIASSAGA II: L. PSYCHOSISSSAGA II: M. ANTISOCIAL PERSONALITYSSAGA II: N. SUICIDAL BEHAVIORSSAGA II: O. POST-TRAUMATIC STRESS DISORDERSSAGA II: P. GENERALIZED ANXIETY DISORDERSSAGA II: Q. OBSESSIVE-COMPULSIVE DISORDERSSAGA II: R. SOCIAL PHOBIASSAGA II: S. AGORAPHOBIASSAGA II: T. PANICSSAGA II: U. COMORBIDITYSSAGA II: V. HOME ENVIRONMENT INTERVIEW--CHILDHOODSSAGA II: W. SUBJECT COMMENTSSSAGA II: X. INTERVIEWER OBSERVATIONSSSAGA II Table of ContentsSSAGA-II Tally SheetAscertainment Procedures for COGA Case-Control SampleEdenberg, 2002; Foroud et al., 2000; Reich et al., 1998). Probands and their relatives were administered a validated poly-diagnostic instrument, the Semi- Structured Assessment for the Genetics of Alcoholism (SSAGA)(Bucholz et al., 1994; Hesselbrock et al., 1999), which allows assessment of alcohol dependence under several diagnostic systems. Genotyping was performed by the Center for Inherited Disease Research (CIDR). DNA sources included blood (n = 1453) and lymphoblastoid cell lines (LCL, n = 492).
]]>Edenberg, 2002; Foroud et al., 2000; Reich et al., 1998). Probands and their relatives were administered a validated poly-diagnostic instrument, the Semi- Structured Assessment for the Genetics of Alcoholism (SSAGA)(Bucholz et al., 1994; Hesselbrock et al., 1999), which allows assessment of alcohol dependence under several diagnostic systems. Genotyping was performed by the Center for Inherited Disease Research (CIDR). DNA sources included blood (n = 1453) and lymphoblastoid cell lines (LCL, n = 492).
]]>Edenberg, 2002; Foroud et al., 2000; Reich et al., 1998). Probands and their relatives were administered a validated poly-diagnostic instrument, the Semi- Structured Assessment for the Genetics of Alcoholism (SSAGA)(Bucholz et al., 1994; Hesselbrock et al., 1999), which allows assessment of alcohol dependence under several diagnostic systems. Genotyping was performed by the Center for Inherited Disease Research (CIDR). DNA sources included blood (n = 1453) and lymphoblastoid cell lines (LCL, n = 492).
]]>Unrelated individuals were chosen based on diagnoses from the adult SSAGA and SSAGA2 interviews. All subjects consented

to sharing their samples. Both cases and controls were assessed by trained interviewers using the

Semi-Structured Assessment for the Genetics of Alcoholism, a poly-diagnostic instrument.

Cases were alcohol dependent by DSM-IV criteria (at every interview if interviewed more than once). Probands were

preferentially selected. Cases could not come from control pedigrees.

Controls were unaffected for a wide range of dependence phenotypes at every interview (if interviewed more than once).

Controls could not have any alcoholism-related diagnosis (abuse or dependence or harmful use), nor could they have DSM-IIIR or

DSM-IV diagnoses of cocaine abuse or dependence, marijuana abuse or dependence, opioid abuse or dependence, sedative abuse or

dependence, or stimulant abuse or dependence. Similarly, controls could not have ICD10 diagnoses of cocaine dependence, marijuana

dependence, opiate dependence, sedative dependence, or stimulant dependence. Controls could not share a known common ancestor with a

proband. Controls above the age of 25 years were preferentially selected.]]>
COGA was initiated in 1989, with Henri Begleiter as the Principal Investigator and Theodore Reich as the Co-Principal

Investigator for 15 years. In 2004, while Henri Begleiter remained the PI, 4 Co-PIs were put into place: Howard Edenberg,

Victor Hesselbrock, Bernice Porjesz and Laura Bierut. In 2006, the structure of the leadership changed again, with these 4

scientific Co-PIs leading the project, and Bernice Porjesz additionally serving as the Administrative PI. In addition to

Henri Begleiter and Theodore Reich, several past key members of COGA were T.K. Li, Raymond Crowe, Wendy Reich and C. Michael

Conneally, who have moved on to new positions or have retired.

In 1990, Phase I of COGA began, systematically ascertaining probands in treatment within six catchment areas, located

across the United States (Indiana, New York, St. Louis, Connecticut, Iowa, San Diego). Probands met criteria of alcohol

dependence based upon personal interview using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), a polydiagnostic

instrument developed by COGA, and had at least two first-degree relatives available for evaluation. Over the next 5 years,

affected probands and family members participated in the study. During this time, Control families with the same family

structure were also ascertained from the community, to be representative of the general population; controls did not have to

be unaffected individuals. All families completed the same battery of tests. A subset of families underwent

neurophysiological assessments.

In Phase II, between 1995 and 1999, some recruitment of new families continued, and the first follow-up protocol

(5 year) was initiated. Affected families were extended. Adult clinical interviews conducted at this time used the SSAGA2

(a slight modification of the SSAGA to meet new diagnostic criteria).

Phase III began in 1999, and was primarily an extension of Phase II with an emphasis on recruiting high-risk families

with young children. At this time Howard University became an additional recruitment site.

In 2004, COGA began Phase IV, the prospective study of adolescents and young adults from pedigrees ascertained in

Phases I-III, which is ongoing. Participants are reassessed every two years.

For more details, see

zork.wustl.edu/niaaa/coga_instruments/resources.]]>