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Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro and in vivo follicular T helper cells

ChEBI2012-01-05 更新2026-07-21 收录

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细胞可塑性

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-32864 数据链接链接失效反馈

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Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro and in vivo follicular T helper cells

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2012-01-05

豚鼠巨细胞病毒免疫

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In this study, we use recently developed monoclonal antibodies to deplete CD4+ and CD8+ T cells during primary guinea pig cytomegalovirus infections in male and pregnant guinea pigs, and evaluated the

DataCite Commons2024-10-18 更新90

Chromatin Landscape of IL-4-expressing CD4 T cells in the lung and lung-draining lymph nodes. Chromatin Landscape of IL-4-expressing CD4 T cells in the lung and lung-draining lymph nodes

2型免疫反应

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Using bulk-, single cell-, ATAC-, and TCR repertoire sequencing, this study reveals that helminth infection causes the expansion of distinct IL-4-competent CD4+ T cells in the lung and lung-draining l

NIAID Data Ecosystem60

Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity [BeadChipHumanWG-6]

Th17细胞

细胞可塑性

Th17 cells have been investigated in mice primarily for their contributions to autoimmune diseases. However, the pathways of differentiation of Th17 and related Th cells (type 17 cells) and the struc

NIAID Data Ecosystem50

Gene expression analysis of Ox40-cre/ROSA-YFP CD4+ T cell subsets. Mus musculus

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细胞表型分析

An Ox40-cre allele was used for lineage marking of CD4 T cells. Naive T cells that had previously expressed OX40 demonstrated a partially activated phenotype that was distinct from that of the majorit

NIAID Data Ecosystem80

Transient expression of T-bet epigenetically imprints the Ifng locus for its expression in a distinct Tfh cell subset

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表观遗传调控

T follicular helper (Tfh) cells, which reside in the B cell follicles and help Ig class switching, express the master transcription factor BCL-6 and signature cytokine IL-21. Tfh cells are also capabl

NIAID Data Ecosystem50

Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro and in vivo follicular T helper cells

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