The protective role of hydrogen sulfide and its impact on gene expression profiling in rat model of COPD

To investigate the role of H2S in Chronic obstructive pulmonary disease (COPD), a rat model of COPD was established by cigarette smoking (CS) and intratracheal instillation of lipopolysaccharide (LPS). Rats were randomly divided into 4 groups: Control, CS+LPS, CS+LPS+NaHS and CS+LPS+propargylglycine (PPG). Transcription profiling of lung tissue comparing Control with CS+LPS, CS+LPS with CS+LPS+NaHS, and CS+LPS with CS+LPS+PPG. The goal was to determine the impact of H2S on gene expression profiling in rat model of COPD. 4 groups, Control vs. CS+LPS; CS+LPS vs. CS+LPS+NaHS; CS+LPS vs. CS+LPS+PPG; each group has 3 replicates.