ImmunoSPdb: A repository of immuno-suppresive peptides

Welcome to the official documentation for ImmunoSPdb, a comprehensive, manually curated database of experimentally verified immunosuppressive peptides. Immunosuppressive peptides are vital for reducing the efficacy of the immune system and have a wide range of therapeutic implementations, particularly in treating autoimmune disorders, asthma, and managing organ transplantation. Web Server: http://webs.iiitd.edu.in/raghava/immunospdb/ Citation Usmani, S. S., Agrawal, P., Sehgal, M., Patel, P. K., & Raghava, G. P. S. (2019). ImmunoSPdb: an archive of immunosuppressive peptides. Database, 2019, baz012. https://doi.org/10.1093/database/baz012 GitHub:-https://github.com/Manish-IIITD-repository/ImmunoSPdb About the Platform ImmunoSPdb was developed to provide a centralized resource for researchers exploring peptides that can modulate the immune response. While traditional immunosuppressive drugs often have systemic side effects, peptide-based therapies offer a more targeted approach. ImmunoSPdb compiles scattered experimental data into a structured format to accelerate the discovery and design of novel immunosuppressive leads. Database Statistics Peptide Entries: Contains approximately 500 experimentally verified immunosuppressive peptides. Data Sources: Information is meticulously compiled from 79 research articles. Species Diversity: Includes peptides tested against various immune cells (e.g., T-cells, B-cells, macrophages) from different organisms. Key Features Search and Browse Modules Simple Search: Quick keyword searching based on peptide name, sequence, or source. Advanced Search: Complex querying using logical operators (AND/OR) across multiple fields like assay type, target cell, and inhibition level. Browsing: Explore the database by specific categories such as the nature of the peptide (natural vs. synthetic) or the immune assay performed. Comprehensive Annotations Functional Data: Details on the immunosuppressive activity, including the percentage of inhibition or IC50 values where available. Assay Information: Information on the experimental conditions, cell lines used, and biological markers measured (e.g., cytokine levels). Peptide Properties: Physical and chemical properties of the peptides are provided to assist in structure-activity relationship (SAR) studies. Technical Overview ImmunoSPdb is built on a robust architecture to facilitate easy data retrieval and analysis. Backend: Managed using a MySQL database for organized data storage. Web Interface: Developed using PHP, HTML, and JavaScript to provide a user-friendly and responsive experience. Integrated Tools: Includes modules for sequence alignment and links to external resources like PubMed and UniProt. Applications Drug Discovery: Identifying lead peptides for the treatment of inflammatory and autoimmune diseases. Vaccine Design: Assisting in the design of vaccines where immune modulation is necessary. Basic Research: Providing a high-quality dataset for bioinformatics analysis and the development of predictive machine-learning models. Contact & Authors Prof. Gajendra P.S. Raghava Department of Computational Biology, Indraprastha Institute of Information Technology (IIIT-Delhi), New Delhi, India. Email: [e-mail] / [e-mail] License This resource is open-access and distributed under the terms of the Creative Commons Attribution License, permitting unrestricted use and distribution provided the original work is properly credited.