Additional file 1 of Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease

Additional file 1: Table S1. Temporal profiles of the levels of differentially expressed proteins in the brain of APP-KI mice. Fold change was calculated using the intensities in the brains of age-matched APP-KI and WT mice as estimated by DIA-NN. P-values were estimated using Welch’s test. Data points represent mean ± SD values (n = 3–5). Table S2. Temporal profiles of the levels of differentially expressed proteins in isolated brain capillaries of APP-KI mice. Fold change was calculated using the counts in the isolated brain capillaries of age-matched APP-KI and WT mice as estimated by DIA-NN. P-values were estimated using Welch’s test. Data points represent mean ± SD values (n = 3–5). Table S3. Temporal profiles of the levels of significantly different ABC and SLC transporter proteins in the brain capillaries of APP-KI mice. Fold change was calculated using the counts in isolated brain capillaries of age-matched APP-KI and WT mice as estimated by DIA-NN. P-values were estimated using Welch’s test. Data points represent mean ± SD values (n = 3–5). Table S4. Temporal profiles of the levels of ABC and SLC transporter proteins in the brain of APP-KI mice. Fold change was calculated using the counts in the brains of age-matched APP-KI and WT mice as estimated by DIA-NN. P-values were estimated using Welch’s test. Data points represent mean ± SD values (n = 3–5). Table S5. Temporal profiles of the levels of proteins related to receptor-mediated transcytosis in the brain capillaries of APP-KI mice. Fold change was calculated using the counts in the brains of age-matched APP-KI and WT mice as estimated by DIA-NN. P-values were estimated using Welch’s test. Data points represent mean ± SD values (n = 3–5). Table S6. Temporal profiles of Aβ production and clearance in the brain and brain capillaries of APP-KI mice. Fold change was calculated using the counts in the brain and isolated brain capillaries of age-matched APP-KI and WT mice as estimated by DIA-NN. P-values were estimated using Welch’s test. Data points represent mean ± SD values (n = 3–5).