Single-cell transcriptome atlas of mammalian hair cells uncovers the molecular mechanisms underlying tonotopic differences

our study discloses the mechanisms underlying the tonotopic map establishment and maintenance in mammalian HCs, and provides an important foundation for further elaborating the mechanisms of HCs in response to different frequencies. Comparing the molecular composition and molecular function of hair cells in different parts of the cochlea. Each sample represents a single cell.本研究揭示了哺乳动物毛细胞（Hair Cells，HCs）中音调拓扑图谱（tonotopic map）的建立与维持机制，为进一步阐明毛细胞响应不同频率的作用机制提供了重要基础。本研究还比较了耳蜗不同部位毛细胞的分子组成与分子功能，每个样本均对应单个细胞。