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The ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition. The ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

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NIAID Data Ecosystem2026-03-11 收录
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We show synthetic lethality between PLK4 inhibition-mediated centrosome loss and the overexpression of the ubiquitin ligase TRIM37 in cancer cells with amplification of Chr17q Overall design: Compare the effect of differential TRIM37 expression on global gene expression in untransformed hTERT RPE1 and neuroblastoma CHP-134 cells.

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2020-04-07
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