The dietary sweetener sucralose is a negative modulator of T-cell- mediated responses

Sucralose is an artificial sweetener commonly used in food and drinks to increase food palatability and control total calorie content. While it is approved for human consumption by both the EFSA and the FDA, recent reports have questioned the safety of long-term consumption of s. in this study, we show that high doses of sucralose affect immune responses in different mouse models of autoimmunity, infection, and cancer. Similarly, sucralose impedes proper t cell proliferation and polarization in vitro. Mechanistically, sucralose dampens signals downstream the TCR resulting in decrease calcium flux upon TCR activation. Comparative gene expression profiling analysis of RNA-seq data for primary murine T cells on either TCM, sucralose or saccharin exposed for 24 and 48 hours.