Synthesis and Characterization of Platinum(IV) Anticancer Drugs with Functionalized Aromatic Carboxylate Ligands: Influence of the Ligands on Drug Efficacies and Uptake

A series of trans-platinum(IV) complexes with functionalized aromatic carboxylate ligands,
cis,cis,trans-Pt(NH3)2Cl2(CO2C6H4R)2 (R = H (3), p-vinyl (4), p-methoxy (5), p-iodo (6), p-cyano
(7), or o-carboxyl (8)) was synthesized and characterized by spectroscopic methods. Crystal
structures of 3, 4, 7, and 8 were obtained, which revealed that their structural conformations
were influenced by intramolecular H-bonding interactions. The complexes were evaluated for
cellular uptake and inhibition of cell proliferation against a panel of lung, colon, and breast
carcinoma cell lines. The functionalization of the aromatic carboxylate ligand was found to
have a profound influence on the uptake, and hence, efficacy, of this class of complex.