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Consticted migration is associated with stable 3D genome structure differences in cancer cells (Hi-C)

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE143676
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We investigated the effect of constricted migration (using transwell assays with 5-μm or 12-μm in diameter) on the organization of the 3D genome in melanoma and breast cancer cells. Hi-C was performed to investigate changes in 3D genome organization after constricted migration. This experiment was performed on all sub-populations of A375 with two biological replicates per condition.
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2022-11-29
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