Regulation of the circadian rhythmic expression of <i>Sglt1</i> in the mouse small intestine through histone acetylation and the mRNA elongation factor, BRD4-P-TEFb

Jejunal sodium/glucose co-transporter (<i>Sglt1</i>) displays circadian expression. The jejunum was collected every 4 h from mice, and we examined histone acetylation and binding of bromodomain-containing protein-4 (BRD4) around of the gene. Histone acetylation increased in the transcribed region of <i>Sglt1</i> prior to induction of the gene. Furthermore, the binding of mRNA elongation factor around the gene showed circadian rhythm.