Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM679 (ethyl 1,4-dimethyl-5-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrazole-3-carboxylate)

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM679 (ethyl 1,4-dimethyl-5-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrazole-3-carboxylate) Descriptor: 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, CITRIC ACID, Dihydroorotate dehydrogenase (quinone), ... Authors: Deng, X, Tomchick, D, Phillips, M. Deposit date: 2024-09-05 Release date: 2025-01-01 Last modified: 2025-01-29 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J.Med.Chem., 68, 2025