NSD2 amplifies oncogenic transcriptional output to promote lung adenocarcinoma pathogenesis [RNA-seq]

RNA-seq of kras and kras;NSD2 driven tumor biopsies and RNA-seq and Cut-and-run of kras;NSD2 derived cells suggests NSD2 amplifies Ras-output at chromatin and separately activates oncogenic-promoting gene expression programs. RNA-seq was performed using tumor biopsies from kras and kras;NSD2 mice and compared to wild type lungs. In a separate study, RNA-seq and cut and run was performed in cell lines derived from the tumor biopsies of kras;NSD2 mice (KN cells±sgNSD2).