Trafficking of <i>Francisella</i> within macrophages (A) and amoebae cells (B).
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(A) Upon phagocytosis by macrophages, bacteria reside in the FCP that interact with early (EEA1 and Rab 5) and late (Lamps and Rab 7) endocytic compartments. The FCP is rapidly acidified by the vATPase proton pump, resulting in bacterial escape into the cytosol, where it replicates. (B) After phagocytosis by amoebae, bacteria are localized in intact vacuoles. Bacteria reside in the vacuoles and replicate.
创建时间：
2016-02-23
