Changes in baseline RSNA (%) and MAP (mmHg) in response to the microinjection of saline, L-NAME (100 nmol), SNP (50 nmol), Nω-propyl (5 nmol), L-NIO (50 nmol) or SMT (500 pmol) into the PVN of the Control and IR rats.

The values are expressed as the means±SE. n = 6 for each group.*P#PPVN: paraventricular nucleus; RSNA: renal sympathetic nerve activity; MAP: meanarterial pressure; IR: insulin resistance. For each side of the PVN, the microinjection volume was 50 nL for each chemical used in this study. Baseline RSNA and MAP were determined based on a 2-min average of their maximal response after PVN microinjection.Changes in baseline RSNA (%) and MAP (mmHg) in response to the microinjection of saline, L-NAME (100 nmol), SNP (50 nmol), Nω-propyl (5 nmol), L-NIO (50 nmol) or SMT (500 pmol) into the PVN of the Control and IR rats.