Single-cell transcriptome reveals drug-resistance signature and immunosuppressive microenvironment in lung adenocarcinoma harboring EGFR mutations. Homo sapiens

Six advanced LUAD patients harboring EGFR mutations were enrolled in this study, and tumor tissues were collected from 3 initially diagnosed (ID group) and 3 EGFR-TKIs resistant (Resistance group) individuals. Single-cell transcriptome landscapes of tumor samples were profiled. Subsequently, the differences in TME composition, functional phenotype of clusters, and cell-cell communications between the two groups were systematically analyzed.