Functional study and identification of transcription factors that regulate aflatoxin biosynthesis and oxidative response

Aflatoxin (AF) is a notorious mycotoxin and consumption of AF contaminated foods and feeds poses a serious threat to humans and animals. AF biosynthesis has become an excellent model for exploring the genetic regulation of secondary metabolism in fungi. This study found that the kinetochore protein Spc105 regulate secondary metabolism and provide new insight for AF synthesis regulation.