Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer [scCRISPR]. Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer [scCRISPR]
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下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA896168
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资源简介：
The gene regulatory network (GRN) underlying CTL differentiation and whether Tex responses can be functionally reinvigorated are incompletely understood. Here, we systematically mapped causal GRNs via single-cell CRISPR (scCRISPR) screens in vivo and discovered checkpoints for CTL differentiation. Overall design: We used scCRISPR to identify the TF regulatory network of transcriptional heterogeneity of OT-I Tcells at day 7 post adoptive transfer into B16-OVA tumors
创建时间：
2022-10-31
