Transcriptional profiling of swine lung and hilar node after experimental infection with Actinobacillus pleuropneumoniae. Sus scrofa

This study aimed at: (1) Establishing the pleuropneumoniae pathological model of artificial infection; (2) Using the Agilent swine genome-wide microarray containing 43,603 probes to detect the changes in gene expression of infected pigs’ lungs and hilar nodes. Overall design: Infection induced gene expression in swine lung and hilar node were measured at 48 hours after being inoculated with 1 mL containing 3.8 × 10^7 cfu/mL pleuropneumoniae serotype I by atomizing inhalation in each nostril.