Proteomic and metabolomic profiling identified plasma biomarkers of motion sickness susceptibility in healthy Chinese males

Motion sickness (MS) is defined as a disorder with cardinal manifestations including nausea-related syndrome (i.e. epigastric discomfort, pallor, cold sweating, hypersalivation nausea and vomit) and sopite-related symptoms (i.e. drowsiness, lethargy, headache and dizziness) induced by passive physical movements 1-4. Precise characterization of molecular profile associated with MS susceptibility is critical for objective MS prediction and diagnosis and help to clarify molecular basis underlying MS symptoms. As varieties of environmental aspects (motion pattern, temperature and smells) and individual characters (gender, age, race, personality and genetic background) affect individual differences in MS susceptibility 5-8, it is still a great challenge for objective discriminating susceptible (SUS) and non-susceptible (nonSUS) subjects among normal populations. Identification of circulation biomarkers receive great concerns due to the successful application of high-throughput multi-omics technology in discovering