Peptide GPCRs

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. [https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor Wikipedia] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP24 CPTAC Assay Portal]

G蛋白偶联受体（G protein–coupled receptors，简称GPCRs），亦称七跨膜结构受体、7TM受体、七螺旋受体、蛇形受体以及G蛋白连接受体（G protein–linked receptors，简称GPLR），构成了一大家族的大蛋白质受体，该受体能够检测细胞外的分子并激活内部信号转导途径，最终引发细胞反应。通过与G蛋白的偶联，它们被称为七跨膜受体，因为它们穿过细胞膜七次。详情请见[https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor Wikipedia]网站。该途径上的蛋白质具有通过[https://assays.cancer.gov/available_assays?wp_id=WP24 CPTAC检测门户]提供的靶向检测方法。