Solubility Behaviors and Correlations of Common Solvent–Antisolvent Systems

This report is a follow-up to our
two prior publications that analyzed
solubility behaviors and correlations of common solvents. The statistical
results reported herein, on a large number of common solvent–antisolvent
systems, are obtained with the same log/log linear regression methodology.
From the analysis, we have identified strong solubility correlations
in many Type 1 (same solvent/antisolvent, different ratio) and Type
2 (same ratio/antisolvent, different solvent) solvent–antisolvent
system pairs. Many of these solvent mixtures are amenable to solubility
predictions based on a simple extrapolation methodology. These findings
empower scientists to compress and optimize solubility screening designs
by eliminating measurements that are likely to produce redundant information.