Effects of imeglimin and metformin on islets of db/db mice

To investigate the effects of imeglimin and metformin on islet cells in db/db mice, we isolated pancreatic islets from db/db mice treated with/without imeglimin and metformin or db/+ mice. Total RNA samples of islets from db/+ mice (db-1, -2, -3), db/db mice (db/db-Ctrl1, 2, 3), or imeglimin and metformin-treated db/db mice (db/db-ImeMet1, 2, 3) were subjected to RNA-Seq.