CRISPR-mediated biocontainment: Data for figure S2
收藏NIAID Data Ecosystem2026-03-12 收录
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Leveraging transposable elements of the genome to prevent Cas9 editing and design a safety-switch for cell therapies
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创建时间：
2021-02-28
相关数据集
Quantitative evaluation of chromosomal rearrangements in primary gene-edited human stem cells by preclinical CAST-Seq. Quantitative evaluation of chromosomal rearrangements in primary gene-edited human stem cells by preclinical CAST-Seq
Genome editing with programmable nucleases has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by chromosomal translocations or the insertion of mutation
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Table 2.1 Guide 2 off-target locations
Guide RNA sequence and in silico predicted off-target locations as determined using an online tool (http://crispr.mit.edu). Pairs of bidirectional sgRNAs were used in conjunction with a mutant Cas9 D1
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Safeguarding genome integrity during gene-editing therapy of age-related macular degeneration. Safeguarding genome integrity during gene-editing therapy of age-related macular degeneration
Ensuring genome safety during gene editing is crucial for clinical translation of the high-efficient CRISPR-Cas9 toolbox. Therefore, the undesired events including chromosomal translocations, vector i
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Frequent and extensive Cas9-directed genomic damage
CRISPR/Cas9 is poised to become the gene editing tool of choice in clinical contexts, but the full spectrum of on-target damage remains unknown. Thus far, exploration of Cas9 induced genetic alteratio
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Chromomal translocations induced by CRISPR-Cas9 persist in expanded T cells
Chromosomal translocations cause various lymphoid cancers and are prevalent in CRISPR-Cas9-meidated gene editing. However, the fate of gene editing-induced translocations remains elusive in vivo. Here
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