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Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

ChEBI2014-09-05 更新2026-07-21 收录

RNA剪接调控

强直性肌营养不良机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-60487 数据链接链接失效反馈

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Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

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创建时间：

2014-09-05

RNA剪接调控

METTL3

To identify changes in splicing patterns following METTL3 knockdown, RNA-sequencing was performed on nuclear RNA extracted from cells transfected with METTL3-targeting siRNA or a non-targeting siRNA (

NIAID Data Ecosystem60

DataSheet2_Nuclear envelope transmembrane proteins involved in genome organization are misregulated in myotonic dystrophy type 1 muscle.PDF

强直性肌营养不良机制

核膜跨膜蛋白功能异常

Myotonic dystrophy type 1 is a multisystemic disorder with predominant muscle and neurological involvement. Despite a well described pathomechanism, which is primarily a global missplicing due to sequ

NIAID Data Ecosystem40

ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing

RNA剪接调控

神经元mRNA处理

ELAV/Hu factors are conserved RNA binding proteins that play diverse roles in mRNA processing and regulation. The founding member, Drosophila Elav, was recognized as a vital neural factor 35 years ago

NIAID Data Ecosystem40

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

RNA剪接调控

肿瘤免疫治疗

Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within cancer cells could similarly result in ne

NIAID Data Ecosystem50

The impact of Prp18p on splicing fidelity and efficiency in budding yeast

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RNA剪接调控

Fidelity of 3´-splice site (3´SS) selection by the spliceosome is critical for proper gene expression but is a daunting task considering the low complexity of the 3´SS consensus YAG. Here we show that

Alliance of Genome Resources40

Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

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