Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor

Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor Descriptor: (5S)-1-benzyl-3-(1,1-dioxido-1,2-benzisothiazol-3-yl)-4-hydroxy-5-(1-methylethyl)-1,5-dihydro-2H-pyrrol-2-one, RNA-directed RNA polymerase Authors: Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. Deposit date: 2008-05-07 Release date: 2009-05-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008