A Total Synthesis of Bifidenone
收藏NIAID Data Ecosystem2026-03-10 收录
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https://figshare.com/articles/dataset/A_Total_Synthesis_of_Bifidenone/4806721
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资源简介：
The
first total synthesis of bifidenone, a novel natural tubulin
polymerization inhibitor, has been achieved in 12 steps starting from
commercially available 1,4-dioxaspiro[4.5]decan-8-one. The synthesis
includes a newly developed method to generate the dihydrobenzodioxolone
core by palladium-catalyzed aerobic dehydrogenation. The three stereocenters
were installed with an AD-mix-β dihydroxylation step followed
by a late-stage palladium-catalyzed decarboxylation–allylation
procedure. The absolute stereochemistry of 3 was determined
via 13a by single-crystal X-ray analysis.
创建时间：
2017-03-31
