Crystal structure of human CD73 (ecto-5'-nucleotidase) in complex with the AMPCP analog PSB-17230 in the closed state (crystal form IV)

Crystal structure of human CD73 (ecto-5'-nucleotidase) in complex with the AMPCP analog PSB-17230 in the closed state (crystal form IV) Descriptor: 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[2-chloranyl-6-[(phenylmethyl)-propyl-amino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid Authors: Strater, N, Moschuetz, S, Idris, R.M, Al-Hroub, H, Schmies, C.C, Muller, C.E. Deposit date: 2025-01-16 Release date: 2025-06-11 Last modified: 2026-03-11 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Design, development and evaluation of a tritium-labeled radiotracer for ecto-5'-nucleotidase (CD73) - A versatile research tool and diagnostic agent for personalized medicine. Biomed Pharmacother, 188, 2025