Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I

Protein Data Bank Japan2024-11-20 更新2026-03-21 收录

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Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... Authors: Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. Deposit date: 2003-12-08 Release date: 2004-07-06 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004

创建时间：

2003-12-08