Transcriptional profile of MRE deficient BLaER1 monocytes [RNA MRE]

We have identified a MORC3-regulated DNA element (MRE) that regulates the activation of IFNB1 upon loss of MORC3. To study the global transcriptional effects of the MRE, we deleted the MRE in STAT1–/– STAT2–/– and STAT1–/– STAT2–/– MORC3–/– BLaER1 monocytes and performed RNA-seq. Overall design: Monoclonal gene-deficient BLaER1 monocytes in two independent experiments.